ABSTRACT
Patients with chest pain presenting to emergency rooms are currently investigated using either invasive coronary angiography (ICA) or non-invasive computer tomography coronary angiography (CTCA). ICA remains an expensive diagnostic tool and exposes patients to a highest risk of periprocedural complication. Beside the current available expansive economic evidence base there is still a main lingering issue: to establish, from the point of view of healthcare provider, which is the most cost-effective investigation tool for the detection of significant coronary artery disease. The aim of this article is to present the latest developments in the field of imaging tools for detection of coronary atherosclerosis in patients with chest pain, from the perspective of cost-effectiveness analysis.